apical membrane
The definitions used in this glossary of terminology either have been provided by the authors of the articles, or have been extracted wholly or in part, or paraphrased from the following sources: The American Medical Association Encyclopedia of Medicine, Charles B. Clayman, MD, Medical Editor, Random House, New York, 1989; Biotechnology from A to Z, 2d Edition, William Bains, Oxford University Press, New York, New York, 2002; A Dictionary of Genetics, 6th Edition, Robert C. King and William D. Stansfield, Oxford University Press, New York, New York, 2002; Dorland's Illustrated Medical Dictionary, 29th and 30th Editions, W. B. Saunders Company, Philadelphia, 2000, 2003; Genes VII, Benjamin Lewin, Oxford University Press, New York, New York, 2000; The Gale Encyclopedia of Genetic Disorders, Volumes I and II, Stacey L. Blachford, Ed., Thomson Learning, New York, New York, 2002; The Merriam-Webster Dictionary, Merriam-Webster, Inc., Springfield, Massachusetts, 1997; Molecular Biology of the Cell, 3rd Edition, Bruce Alberts, et al., Garland Publishing, 1994; The Random House Dictionary of the English Language, Unabridged Edition, 1966; Webster's Ninth New Collegiate Dictionary, 1991.
DEFINITION:
- apical membrane
-
See under membrane.
Used in 54 Article abstracts
Used in 54 Article abstracts
- A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial Cells
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- Annexin A4 Reduces Water and Proton Permeability of Model Membranes but Does Not Alter Aquaporin 2-mediated Water Transport in Isolated Endosomes
- Antidiuretic Hormone Modulates Membrane Phosphoproteins in Toad Urinary Bladder and Retrieved Water Channel Containing Apical Membrane Vesicles
- Apical Extracellular Calcium/Polyvalent Cation-sensing Receptor Regulates Vasopressin-elicited Water Permeability in Rat Kidney Inner Medullary Collecting Duct
- Apical Membrane Vesicles of ADH-stimulated Toad Bladder are Highly Water Permeable
- Aquaporin-2 Trafficking is Regulated by PDZ-domain Containing Protein SPA-1
- Aquaporin-2 transfection of Madin-Darby canine kidney cells reconstitutes vasopressin-regulated transcellular osmotic water transport.
- Aquaporin-2: COOH Terminus is Necessary But Not Sufficient for Routing to the Apical Membrane
- Characterization of Purified Endosomes Containing the Antidiuretic Hormone-Sensitive Water Channel From Rat Renal Papilla
- Cloning and Expression of Apical Membrane Water Channel of Rat Kidney Collecting Tubule
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Development of Lithium-Induced Nephrogenic Diabetes Insipidus is Dissociated from Adenylyl Cyclase Activity
- Effect of an Acute Oral Ibuprofen Intake on Urinary Aquaporin-2 Excretion in Healthy Humans
- Fate of Antidiuretic Hormone Water Channel Proteins after Retrieval from Apical Membrane
- Functional involvement of Annexin-2 in cAMP induced AQP2 trafficking.
- Heat Shock Protein 70 Interacts with Aquaporin-2 (AQP2) and Regulates Its Trafficking
- Heteroligomerization of an Aquaporin-2 Mutant with Wild-Type Aquaporin-2 and Their Misrouting to Late Endosomes/Lysosomes Explains Dominant Nephrogenic Diabetes Insipidus
- Identification of Specific Apical Membrane Polypeptides Associated With the Antidiuretic Hormone-Elicited Water Permeability Increase in the Toad Urinary Bladder
- Identification of a Multiprotein "Motor" Complex Binding to Water Channel Aquaporin-2
- Induction of Intramembranous Particle Clusters in Mice with Nephrogenic Diabetes Insipidus
- Insulin Potentiates AVP-induced AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
- Isolation and Characterization of Specialized Regions of Toad Urinary Bladder Apical Plasma Membrane Involved in the Water Permeability Response to Antidiuretic Hormone
- Kinetic Model of Water and Urea Permeability Regulation by Vasopressin in Collecting Duct
- Kinetics of Urea and Water Permeability Activation by Vasopressin in Rat Terminal IMCD
- Loss of Calcineurin Aα Results in Altered Trafficking of AQP2 and in Nephrogenic Diabetes Insipidus
- MAL Decreases the Internalization of the Aquaporin-2 Water Channel
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Methyl-β-Cyclodextrin Induces Vasopressin-Independent Apical Accumulation of Aquaporin-2 in the Isolated, Perfused Rat Kidney
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Molecular Pathogenesis of Nephrogenic Diabetes Insipidus
- Molecular and Cellular Biology of Vasopressin and Oxytocin Receptors and Action in the Kidney
- Polarized Expression of the Vasopressin V2 Receptor in Madin-Darby Canine Kidney Cells
- Purification and Partial Characterization of Candidate Antidiuretic Hormone Water Channel Proteins of Mr 55,000 and 53,000 from Toad Urinary Bladder
- Quantitation and Topography of Membrane Proteins in Highly Water-Permeable Vesicles From ADH-Stimulated Toad Bladder
- Rat Kidney Papilla Contains Abundant Synaptobrevin Protein that Participates in the Fusion of Antidiuretic Hormone-regulated Water Channel-containing Endosomes In Vitro
- Regulation of Membrane Permeability by Vasopressin; Activation of the Water Permeability Pathway in Toad Urinary Bladder by N-Ethyl-Maleimide
- Relationship Between Vasopressin-Sensitive Water Transport and Plasma Membrane Fluidity in Kidney Collecting Tubule
- Rho Inhibits cAMP-Induced Translocation of Aquaporin-2 into the Apical Membrane of Renal Cells
- Role of Aquaporin Water Channels in Kidney and Lung
- Role of the Cytoplasmic Termini in the Sorting and Shuttling of the Aquaporin-2 Water Channel
- Routing of the aquaporin-2 water channel in health and disease.
- Short-Chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel
- The Apical Compartment: Trafficking Pathways, Regulators and Scaffolding Proteins
- The C-Terminal Tail of Aquaporin-2 Determines Apical Trafficking
- The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel
- Three Families with Autosomal Dominant Nephrogenic Diabetes Insipidus Caused by Aquaporin-2 Mutations in the C-terminus
- Transepithelial Water Flow Regulates Apical Membrane Retrieval in Antidiuretic Hormone-Stimulated Toad Urinary Bladder
- Vasopressin Activates Collecting Duct Urea Transporters and Water Channels by Distinct Physical Processes
- Vasopressin Receptors in Health and Disease
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Vasopressin- and cAMP-Induced Changes in Ultrastructure of Isolated Perfused Inner Medullary Collecting Ducts
- Water Channel Aquaporin-2 Directly Binds to Actin
- Water Channels and Urea Transporters
Used in 81 Article translations
Used in 81 Article translations
- A Novel Mechanism in Recessive Nephrogenic Diabetes Insipidus: Wild-Type Aquaporin-2 Rescues the Apical Membrane Expression of Intracellularly Retained AQP2-P262L
- Activation of the Vasopressin-sensitive Water Permeability Pathway in the Toad Bladder by N-ethyl Maleimide
- An Impaired Routing of Wild-type Aquaporin-2 after Tetramerization with an Aquaporin-2 Mutant Explains Dominant Nephrogenic Diabetes Insipidus
- Antidiuretic Hormone Modulates Membrane Phosphoproteins in Toad Urinary Bladder and Retrieved Water Channel Containing Apical Membrane Vesicles
- Apical Membrane Vesicles of ADH-stimulated Toad Bladder are Highly Water Permeable
- Aquaporin-2 Trafficking is Regulated by PDZ-domain Containing Protein SPA-1
- Aquaporin-2 Water Channel Mutations and Nephrogenic Diabetes Insipidus: New Variations on a Theme
- Cellular Distribution of the Aquaporins: A Family of Water Channel Proteins
- Cloning of an Aquaporin Homologue Present in Water Channel Containing Endosomes of Toad Urinary Bladder
- Cloning, Characterization, and Chromosomal Mapping of Human Aquaporin of Collecting Duct
- Constitutive and Regulated Membrane Expression of Aquaporin 1 and Aquaporin 2 Water Channels in Stably Transfected LLC-PK1 Epithelial Cells
- Current Understanding of the Cellular Biology and Molecular Structure of the Antidiuretic Hormone-stimulated Water Transport Pathway
- Cytoplasmic Dilution Induces Antidiuretic Hormone Water Channel Retrieval in Toad Urinary Bladder
- Disordered Water Channel Expression and Distribution in Acquired Nephrogenic Diabetes Insipidus
- Downregulation of Aquaporin-2 Parallels Changes in Renal Water Excretion in Unilateral Ureteral Obstruction
- Dual Actions of Vasopressin and Oxytocin in Regulation of Water Permeability in Terminal Collecting Duct
- Endosomes from Kidney Collecting Tubule Cells Contain the Vasopressin-sensitive Water Channel
- Evidence for Stabilization of Aquaporin-2 Folding Mutants by N-linked Glycosylation in the Endoplasmic Reticulum
- Fate of Antidiuretic Hormone Water Channel Proteins after Retrieval from Apical Membrane
- From Vasopressin Receptor to Water Channel: Intracellular Traffic, Constraint and By-pass
- Functional Studies of Twelve Mutant V2 Vasopressin Receptors Related to Nephrogenic Diabetes Insipidus: Molecular Basis of a Mild Clinical Phenotype
- Functional Water Channels Are Present in Clathrin-coated Vesicles from Bovine Kidney but Not from Brain
- Heat Shock Protein 70 Interacts with Aquaporin-2 (AQP2) and Regulates Its Trafficking
- Hereditary Nephrogenic Diabetes Insipidus
- High Proton Flux through Membranes Containing Antidiuretic Hormone Water Channels
- Identification of Rab3-, Rab5a- and Synaptobrevin II-like Proteins in a Preparation of Rat Kidney Vesicles Containing the Vasopressin-Regulated Water Channel
- Indomethacin Enhances Shuttling of Aquaporin-2 Despite Decreased Abundance in Rat Kidney
- Insulin Potentiates AVP-induced AQP2 Expression in Cultured Renal Collecting Duct Principal Cells
- Isolation of Human aquaporin-CD Gene
- Kinetic Model of Water and Urea Permeability Regulation by Vasopressin in Collecting Duct
- Kinetics of Urea and Water Permeability Activation by Vasopressin in Rat Terminal IMCD
- Lithium-induced Nephrogenic Diabetes Insipidus
- MAL Decreases the Internalization of the Aquaporin-2 Water Channel
- Mechanism of Antidiuresis Caused by Bendroflumethiazide in Conscious Rats with Diabetes Insipidus
- Mechanism of Vasopressin Action in the Renal Collecting Duct
- Mechanisms and Regulation of Water Permeability in Renal Epithelia
- Mechanisms and Regulation of Water Transport in the Kidney
- Misfolding of Mutant Aquaporin-2 Water Channels in Nephrogenic Diabetes Insipidus
- Molecular Aspects of Water Transport
- Molecular Mechanisms and Drug Development in Aquaporin Water Channel Diseases: Molecular Mechanism of Water Channel Aquaporin-2 Trafficking
- Molecular Mechanisms for the Regulation of Water Transport in Amphibian Epithelia by Antidiuretic Hormone
- Nephrogenic Diabetes Insipidus (Bichet - November 1998)
- Oxytocin Induces Apical and Basolateral Redistribution of Aquaporin-2 in Rat Kidney
- Pathogenesis and Treatment of Autosomal-Dominant Nephrogenic Diabetes Insipidus Caused by an Aquaporin 2 Mutation
- Pathophysiology of Aquaporin-2 in Water Balance Disorders
- Phenotypes Developed in Secretin Receptor-Null Mice Indicated a Role for Secretin in Regulating Renal Water Reabsorption
- Physiology and Pathophysiology of Aquaporins
- Physiology and Pathophysiology of the Aquaporin-2 Water Channel
- Rat Kidney Papilla Contains Abundant Synaptobrevin Protein that Participates in the Fusion of Antidiuretic Hormone-regulated Water Channel-containing Endosomes In Vitro
- Recent Advances in Water Transport
- Regulation of Collecting Duct Water Channel Expression by Vasopressin in Brattleboro Rat
- Regulation of Collecting Duct Water Permeability Independent of cAMP-Mediated AVP Response
- Regulation of Membrane Permeability by Vasopressin; Activation of the Water Permeability Pathway in Toad Urinary Bladder by N-Ethyl-Maleimide
- Relationship Between Vasopressin-Sensitive Water Transport and Plasma Membrane Fluidity in Kidney Collecting Tubule
- Relief of Nocturnal Enuresis by Desmopressin is Kidney and Vasopressin Type 2 Receptor Independent
- Renal Aquaporins
- Reversed Polarized Delivery of an Aquaporin-2 Mutant Causes Dominant Nephrogenic Diabetes Insipidus
- Role of Aquaporin Water Channels in Kidney and Lung
- Rolipram, a Phosphodiesterase Inhibitor, in the Treatment of Two Male Patients with Congenital Nephrogenic Diabetes Insipidus
- Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels
- Short-Chain Ubiquitination Mediates the Regulated Endocytosis of the Aquaporin-2 Water Channel
- Stimulation of AQP2 Membrane Insertion in Renal Epithelial Cells In Vitro and In Vivo by the cGMP Phosphodiesterase Inhibitor Sildenafil Citrate (Viagra)
- The 17 kDa Band Identified by Multiple Anti-Aquaporin 2 Antisera in Rat Kidney Medulla is a Histone
- The Aquaporin Family of Molecular Water Channels
- The Aquaporin Family of Water Channels in Kidney: an Update on Physiology and Pathophysiology of Aquaporin-2
- The C-Terminal Tail of Aquaporin-2 Determines Apical Trafficking
- The Cellular Action of Antidiuretic Hormone
- The Clinical Importance of the Urinary Excretion of Aquaporin-2
- The Perinatal Expression of Aquaporin-2 and Aquaporin-3 in Developing Kidney
- The Role of Membrane Turnover in the Water Permeability Response to Antidiuretic Hormone
- The Role of Putative Phosphorylation Sites in the Targeting and Shuttling of the Aquaporin-2 Water Channel
- Therapeutic Potential of Vasopressin Receptor Antagonists
- Transport Defects of Rabbit Inner Medullary Collecting Duct Cells in Obstructive Nephropathy
- Urinary Excretion of Aquaporin-2 in Humans: A Potential Marker of Collecting Duct Responsiveness to Vasopressin
- Urinary Excretion of Aquaporin-2 in Patients with Diabetes Insipidus
- V2 Vasopressin Receptor Dysfunction in Nephrogenic Diabetes Insipidus Caused By Different Molecular Mechanisms
- Vasopressin Effects on Urea and H20 Transport in Inner Medullary Collecting Duct Subsegments
- Vasopressin Type-2 Receptor and Aquaporin-2 Water Channel Mutants in Nephrogenic Diabetes Insipidus
- Water Channels
- Water Channels in Cell Membranes
- Water Channels in Health and Disease
Used in 15 Proceeding abstracts
Used in 15 Proceeding abstracts
- Regulation of UT-A1 abundance by vasopressin and glucocorticoids
- Aquaporin 2-containing Apical Membrane Endosomes (AQP-2 Endosomes) Possess a Multiprotein Signaling Complex
- Aquaporin-2 Expression in Primary Cultures of Rat Inner Medullary Collecting Duct Cells - A New In-Vitro Model System Facilitating the Study of the Vasopressin-Regulated Antidiuretic Machinery at the Cellular Level
- Defective urinary concentrating function in transgenic mice lacking urea transporter UT-B
- Impaired routing of AQP2 to late endosomes/lysosomes following heterotetramerization with AQP2-E258K is likely to explain dominant nephrogenic diabetes insipidus
- Lack of AVP-induced phosphorylation of the Aquaporin-2 mutants AQP2-R254L and AQP2-R254Q explains dominant Nephrogenic Diabetes Insipidus
- Molecular mechanisms underlying dominant Nephrogenic Diabetes Insipidus caused by mutations in the AQP2 gene
- Mono-ubiquitination and missorting to lysosomes of the Aquaporin-2 water channel mutant AQP2-E258K explains dominant Nephrogenic Diabetes Insipidus
- Production and purification of Aquaporin-2 and Vasopressin 2 Receptor: towards elucidation of the structure
- Purinergic Control of Medullary Collecting Duct Function: A Novel Vasopressin-independent Regulatory Mechanism
- Role of phosphorylation in the trafficking and shuttling of the Aquaporin-2 water channel
- Routing and function of mutant AQP2 water channels in nephrogenic diabetes insipidus
- The C-terminus of aquaporin-2 is necessary, but not sufficient, for routing of AQP2 to the apical membrane
- The novel Aquaporin-2 maturing protein 1 interacts with AQP2, inhibits its forskolin-induced translocation to the apical membrane, and reduces its expression
- The stoichiometry of phosphorylated and non-phosphorylated monomers in an aquaporin-2 tetramer determines its subcellular localization
Used in 9 Proceeding translations
Used in 9 Proceeding translations
- An impaired routing of wild type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus
- Determination of the functionality of AQP2 missense mutants in recessive NDI
- Identification of proteins involved in the vasopressin-induced shuttle of aquaporin-2
- Long-term regulation of aquaporin-2: a possible therapeutic approach to NDI?
- Nephrogenic Diabetes Insipidus in mice lacking aquaporin-3 water channels
- Regulation and distribution of phosphorylated aquaporin-2 (AQP2) in rat kidney collecting duct principal cells
- The C-terminus of aquaporin-2 is necessary, but not sufficient, for routing of AQP2 to the apical membrane
- The stoichiometry of phosphorylated and non-phosphorylated monomers in an aquaporin-2 tetramer determines its subcellular localization
- Vasopressin-V2-receptor dependent and independent regulation of collecting duct aquaporin-2 expression and trafficking



