Frequently Asked Questions
NDI: An Overview
The Nephrogenic Diabetes Insipidus Foundation (NDIF) is dedicated to informing and helping the NDI community. The authors of the information archived on the NDIF website, and the archivists, cannot be held responsible for any damage which may result from using the information on this site without concurrence of your medical doctor. Consult your personal physician for your individual medical needs.
- Am I able to have children if I have NDI? If so, are they likely to get it as well?
- What causes NDI?
- Can I expect my NDI child to be within the normal range of height and weight as an adult?
- Could you explain, in layman's terms, what happens genetically when a father, daughter, and male child of the daughter all have DI?
- Does NDI delay the onset of puberty?
- Does NDI have anything to do with hydrocephalus? My baby boy also has hydro, and they think his is genetic. They were told the mutations are close together.
- How can a girl have NDI? I thought only boys had it.
- How many people have NDI?
- How rare is it for a carrier to have two genetic mutations?
- Is NDI life-threatening, and what symptoms should be watched for?
- Is there any difference in the nature of NDI in a child and NDI in an adult?
- Is there anything I can do to prevent passing the NDI gene on to my children?
- What is the nature of the defect in Aquaporin 2, and how can the symptoms of both autosomal recessive NDI and autosomal dominant NDI be explained by the defect in Aquaporin 2?
- What is the probability that an infant will be born with NDI?
- Will a male child with NDI pass it on to their children? Male or female?
- Will NDI ever go away?



